Installing parts into the Dragon Rider was a breeze compared to other cases I have worked with. I even dare to say it was easier than the Ironclad In-Win released earlier this year. There is just a lot more room to work with than the Ironclad (in my opinion). Cable management was also more manageable, as well. Installing the Cooler Master V10 was a cinch, but as with the Ironclad, you are going to have to remove the 220mm fan to close the door, sadly. Since the side panel takes up to six 120mm fans, using three 120mm fans on the panel should eliminate the predicament with the V10. If worse comes to worse, you would only be able to use 2 120mm on the bottom slots.
As you can see, this CPU cutout is huge, no doubt about it. There will be no problem mounting a cooler to a motherboard while it is inside the case.
In-Win made sure that cable management was easier for everyone. They allow up to about one inch of room to route cables behind the motherboard and such. I honestly wish there was more room, but there is already enough room to do efficient cable routing.